Tuesday, February 10, 2015

REPOST: Study: Opioid Addiction Crisis Fueled by Overprescribing by MDs

Scientists from the Heller School for Social Policy and Management at Brandeis University claim that the overprescription of opioids as painkiller has largely contributed to the rising opioid addiction and overdose deaths in the U.S. PsychCentral.com has the full story below:

Image Source: pyschcentral.com

Policymakers need to look beyond just the recreational abuse of opioids in their efforts to reduce overdose deaths, and focus more on the problem of doctors who are overprescribing opioids as painkillers, said researchers at Brandeis University, the University of North Florida, and Johns Hopkins University.

There also needs to be greater access to opioid addiction treatments, they said.

“We need to prevent new cases of opioid addiction and we need to expand access to treatment for the millions of Americans who are already addicted,” says the study’s lead author, Dr. Andrew Kolodny, of the Heller School for Social Policy and Management at Brandeis University.

“Without better access to addiction treatment, overdose deaths will remain high and heroin will keep flooding in.”

In a new comprehensive study, scientists show that since 2002, new cases of non-medical abuse have gone down, and yet painkiller overdose deaths have soared. This is evidence, they say, that recreational use of painkillers is not a key driver of crisis.

The researchers suggest that policymakers need to focus on preventing new cases of opioid addiction caused by both medical and non-medical use and expanding access to opioid addiction treatment.

The researchers point to the soaring rates of opioid addiction as the explanation for high rates of overdose deaths and the rise of heroin use in non-urban communities. Since 1997, the number of Americans seeking treatment for addiction to painkillers has risen a whopping 900 percent.

The upward trend has been running alongside of the newer practice of prescribing long-term opioids for chronic pain, a practice encouraged by opioid manufacturers.

“I think we have overestimated the benefits of prescription opioids and underestimated their risks,” said study co-author Dr. Caleb Alexander, an associate professor of epidemiology at the Johns Hopkins’ Bloomberg School of Public Health and co-director of the Center for Drug Safety and Effectiveness.

“Although opioids have many risks, their addictive potential is of especially great concern.”

The scientists suggest that some of the same public health strategies used to control disease outbreaks can also be effective in bringing the opioid crisis under control.

Prevention strategies would include public education on the risks of prescription opioids, and wider use of state prescription drug monitoring program (PDMPs) data to alert prescribers to possible doctor-shopping by patients.

“By encouraging and, if necessary, requiring prescribers to use PDMPs, and by pro-actively sending them prescription data on their patients, states can help medical providers intervene at an early stage of addiction and get patients who need it into treatment,” said John Eadie, co-author and director of the PDMP Center of Excellence at Brandeis.

The researchers also suggest increasing access to the addiction medicine buprenorphine and ensuring that naloxone, an opioid overdose antidote, is available to emergency first responders, syringe exchange programs, and family members of people at risk for overdose. The authors assert that opioid addiction has long been overlooked as a key driver of the opioid epidemic, and a new approach is needed.

The paper is published in the journal Annual Review of Public Health.

Joe Schrank and his team at The Core Company of NYC introduce intervention programs to help drug and alcohol-dependents recover. Follow this Twitter account for more discussions on substance abuse and its treatments.

Tuesday, January 20, 2015

Addiction and the pleasure principle: Examining substance abuse motivation

During the 1930s, addiction was believed to be caused by moral flaws or lack of willpower to avoid the addictive substance. Substance abusers were either imprisoned or sent to rehabilitation facilities to break the habit. However, thanks to modern science, addiction is now recognized as a chronic disease that alters brain structure and function, and not just as a moral failure that needs to be punished.

Image Source: recovery.org

The disease “hijacks” the brain and forces it into a series of changes, starting with recognition of pleasure and ending with a drive towards compulsive behavior. Researchers found out that certain activities that induce pleasure such as gambling, sex, and shopping can co-opt the brain.

Image Source: hnetalk.com

All pleasures are registered in the same way in the brain through dopamine (a hormone and neurotransmitter) release. Substance abuse, however, sends a powerful surge of dopamine in the nucleus accumbens, a region in the brain that is interconnected with several other brain areas.


The likelihood of pursuing the pleasurable activity derived from substance abuse is heightened because addictive drugs release 10 times more the amount of dopamine compared to natural rewards and do it with speed, intensity, and reliability. The brain responds to the frequent introduction of the substance by releasing less dopamine every time, thus making the abuser depend on the rewarding activity that will ultimately lead to addiction.

Image Source: drugabuse.gov

Over time, the motivation to take more drugs for a dopamine “high” is down to drug tolerance—the substance no longer gives satisfying amounts of pleasure as expected by the drug abuser and only serves to increase cravings.


As a strong advocate for addiction recovery, Joe Schrank established the Core Company of NYC to help people plan their road to weaning from substance dependencies. Visit the company’s website to learn more about its programs in aid of addicts.